Experimental mRNA therapy protects the liver after acetaminophen overdose

University of Pittsburgh mRNA therapy extends treatment window for acetaminophen overdose in preclinical study

Researchers at the University of Pittsburgh published a study in PNAS demonstrating an experimental mRNA therapy that dramatically extends the treatment window for acetaminophen overdose-related liver injury in preclinical models. The current FDA-approved antidote, N-acetylcysteine, must be administered within hours to be effective.