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Intestinal enzyme links microbial metabolism to MASH progression

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Enzyme UBE2N identified as potential defense against fatty liver disease progression

Researchers at Cedars-Sinai have identified an enzyme called UBE2N that may help protect the liver from damage as fatty liver disease worsens. The enzyme helps liver cells clear damaged mitochondria and break down fat, potentially preventing inflammation and progression toward liver failure in a condition affecting an estimated 100 million Americans.

Sep 29, 2026·4 sourcesMitochondrial functionMetabolic health
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Other sources for this story

Ajmc

Management Strategies for Metabolic Dysfunction–Associated Steatotic Liver Disease (MASLD) | AJMC

Medicalxpress

Promising therapy for fatty liver disease reduces fat, inflammation, and scarring in preclinical models

Sciencedaily

This protective enzyme could help stop fatty liver disease from getting worse