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UCSF Opens Trial: Wearable Ultrasound Silenced Voices in All 3 Schizophrenia Patients

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UCSF launches trial of wearable ultrasound device to treat schizophrenia hallucinations

The University of California, San Francisco opened the MESSI-LEO Phase 1 trial on October 30, testing a wearable 128-element ultrasound headband that targets the caudate region of the brain to reduce auditory hallucinations in schizophrenia patients. The noninvasive treatment addresses persistent hallucinations that affect approximately 40% of patients despite antipsychotic medications.

Oct 30, 2026·2 sourcesNeuroscienceBiomedical engineeringClinical trialsMental Health & WellbeingPsychosis & schizophrenia spectrumMedical innovation
UCSF launches trial of wearable ultrasound device to treat schizophrenia hallucinations
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Researchers test noninvasive ultrasound treatment for schizophrenia-related hallucinations