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BMJ stories

Aug 5, 2026

Study finds diabetes drug tirzepatide reduces heart attack and stroke risk in high-risk patients

New research published in The BMJ shows that tirzepatide (Mounjaro), a GLP-1 receptor agonist, reduces the risk of major cardiovascular events by 33% in type 2 diabetes patients with existing heart disease. A separate study also found that consistent medication adherence among diabetes patients reduces heart disease risk by 27%.

Aug 5, 2026·11 sources
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Top claims

  • ▪In the BMJ study cohort, 35,353 patients started tirzepatide and 17,618 started sitagliptin, with outcomes monitored from the first day of treatment up to one year.
  • ▪Researchers of the BMJ study chose sitagliptin as a neutral placebo proxy because several prior studies have shown it has no effect on cardiovascular outcomes.
  • ▪Researchers Nils Krüger and colleagues stated that trial-anchored evidence from clinical practice can estimate the expected cardiovascular benefits of tirzepatide to inform shared decision-making.

Topics

Medication adherenceCardiovascular health.GLP-1 medications

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