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U.S. Department of Health and Human Services stories

Oct 9, 2026

HHS recommends science-based thresholds to target dangerous enhanced kratom products

HHS provided science-based concentration and ratio thresholds to the DEA on October 9, 2026, targeting 7-hydroxymitragynine (7-OH) and mitragynine pseudoindoxyl (MGPI) in enhanced kratom products without sweeping natural botanical kratom into Schedule I classification.

Oct 9, 2026·1 source
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Top claims

  • ▪7-OH is two to nine times as potent as morphine based on FDA preclinical review
  • ▪R Street Institute argues the 7-OH threshold lacks an established human dose-response link
  • ▪HHS recommended thresholds for 7-OH and MGPI distinguish enhanced kratom from natural botanical kratom

Topics

US health policy & drug pricingAddiction and Harm ReductionKratom Deaths and FDA Regulatory Action

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