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Oct 2, 2026

Retatrutide shows substantial weight loss in type 2 diabetes patients in phase III trial

The investigational triple agonist retatrutide demonstrated significant weight loss and improved glycemic control in adults with obesity and type 2 diabetes in the TRIUMPH-2 phase III trial, with some participants losing up to a quarter of their body weight. Results were presented at the European Association for the Study of Diabetes annual meeting in Milan and published in The Lancet.

Oct 2, 2026·5 sources
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Top claims

  • ▪In the TRIUMPH-2 trial, 72% of participants receiving retatrutide achieved a glycated hemoglobin HbA1c reading of 6.5% or lower at week 80, compared to 29% of participants receiving the placebo.
  • ▪The phase III TRIUMPH-2 clinical trial of Eli Lilly's investigational drug retatrutide was conducted across 92 sites in eight countries and enrolled 1,152 adults with type 2 diabetes and obesity or overweight.
  • ▪In the TRIUMPH-2 trial, retatrutide treatment atop background diabetes therapy resulted in mean HbA1c reductions of 1.38% with the 4-mg dose, 1.50% with the 9-mg dose, and 1.45% with the 12-mg dose.

Topics

Weight managementMetabolic healthBiohacking & optimizationClinical trials

Related entities

Milan