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Multiple sclerosis stories

Oct 23, 2026

Bristol Myers patient died after CAR-T treatment, company explains June trial pause

Bristol Myers Squibb disclosed that a multiple sclerosis patient died from septic pneumonia following zola-cel CAR-T treatment, linking prior adverse events to manufacturing reagent changes. The company plans to restart trials in early 2025.

Oct 23, 2026·5 sources
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Top claims

  • ▪Bristol Myers Squibb voluntarily paused zolacabtagene autoleucel trials in September 2026 to review safety data after observing transient and reversible inflammatory side effects
  • ▪Most multiple sclerosis patients with sufficient follow-up after receiving zolacabtagene autoleucel showed no new disease activity or worsening disability
  • ▪Bristol Myers Squibb disclosed on October 23, 2026, that a patient in an early-stage multiple sclerosis trial died of septic pneumonia 44 days after receiving experimental CAR-T therapy zolacabtagene autoleucel

Topics

Autoimmune disease treatmentsClinical trialsPharmaceutical IndustryDrug safetyCAR T-cell therapy