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Jul 21, 2026

Gilead Sciences and Merck's Once-Weekly HIV Pill Maintains Viral Suppression in Phase 3 Trials

Gilead Sciences and Merck announced that their experimental once-weekly HIV pill combining islatravir and lenacapavir successfully maintained viral suppression at 48 weeks in two Phase 3 trials (ISLEND-1 and ISLEND-2) involving 1,209 adults with virologically suppressed HIV. The results support regulatory filings for what could become the first once-weekly oral HIV treatment regimen.

Jul 21, 2026·7 sources
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  • ▪Gilead Sciences and Merck announced that their once-weekly oral single-tablet regimen of islatravir 2 mg and lenacapavir 300 mg maintained virologic suppression at Week 48 in the Phase 3 ISLEND-1 and ISLEND-2 trials.
  • ▪In the Phase 3 PURPOSE 1 trial open-label extension, no new HIV infections were observed among participants receiving twice-yearly lenacapavir, including those who switched from once-daily oral pre-exposure prophylaxis.
  • ▪In the open-label ISLEND-2 trial, 0.3% of participants taking once-weekly islatravir/lenacapavir had HIV-1 RNA levels at or above 50 copies/mL at Week 48, compared to 1.3% of those who remained on daily standard-of-care regimens.

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Drug developmentPublic healthcare

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