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Bladder cancer stories

May 16, 2026

AstraZeneca's Imfinzi-Enfortumab Vedotin Combination Shows Historic Survival Gains in Bladder Cancer Trial

AstraZeneca's VOLGA trial confirms that the Imfinzi EV combination significantly improves overall survival for cisplatin-ineligible bladder cancer patients, representing a major advancement in treatment for this difficult-to-treat population.

May 16, 2026·1 source
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Top claims

  • ▪Cisplatin-ineligible muscle-invasive bladder cancer patients face high rates of disease recurrence
  • ▪In the VOLGA trial comparator arm, patients underwent radical cystectomy with or without approved adjuvant treatments
  • ▪The perioperative Imfinzi plus enfortumab vedotin combination represents the first perioperative immunotherapy-based combination to show a definitive Overall Survival benefit in cisplatin-ineligible muscle-invasive bladder cancer patients

Topics

Drug Approval and Clinical TrialsPharmaClinical trialsImmunotherapy