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Enzalutamide stories

Oct 26, 2026

FDA expands talazoparib approval for metastatic prostate cancer

The FDA approved the PARP inhibitor talazoparib in combination with enzalutamide for treatment of patients with metastatic androgen pathway modulation-naive or -sensitive prostate cancer.

Oct 26, 2026·2 sources
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Top claims

  • ▪The FDA first approved talazoparib in combination with enzalutamide in June 2023 for patients with HRR gene-mutated metastatic castration-resistant prostate cancer
  • ▪The Phase 3 TALAPRO-3 study enrolled 599 patients with HRR gene-mutated metastatic androgen pathway modulation-naïve or -sensitive prostate cancer across U.S., Canadian, European, South American, and Asia-Pacific sites
  • ▪In the TALAPRO-3 trial, talazoparib plus enzalutamide reduced the risk of radiographic progression or death by 52% compared to placebo plus enzalutamide in patients with HRR-mutated prostate cancer

Topics

Cancer treatmentFDA drug approvalCancer & OncologyOncologyClinical trialsTargeted cancer therapyPrecision medicineDrug Policy, Pricing & Approval

Related entities

TalazoparibPfizer