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Oct 29, 2026

St. Jude researchers discover COMPASS pathway that prevents autoimmune responses to gut bacteria

Scientists at St. Jude Children's Research Hospital have identified a gene-regulatory pathway called COMPASS that enables regulatory T cells to maintain immune tolerance to trillions of bacteria in the human gut. The discovery, published in Science Advances, explains how the body prevents devastating autoimmune responses to intestinal microbes.

Oct 29, 2026·2 sources
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Top claims

  • ▪A study published in Science Advances found that regulatory T cells co-opt the COMPASS gene expression pathway to suppress immune responses against gut microbiota.
  • ▪Loss of Wdr82 deprived regulatory T cells of protective function while inflammatory effector T cells retained their activity, challenging assumptions of uniform gene expression.
  • ▪The COMPASS gene-regulatory pathway enables regulatory T cells under normal conditions to prevent lethal inflammation and autoimmunity in the human intestine.

Subtopics

Autoimmune disease1Biomedical research1CRISPR1Digestive diseases1Gut microbiome1Immune system regulation1Immunology1

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