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Bacteriophages stories

Oct 29, 2026

Picobirnavirus reclassified as bacteriophage, not human pathogen

Researchers have redefined picobirnavirus, a virus found in the human gut microbiome that was long thought to directly infect human tissue and cause gastrointestinal disease, as a bacteriophage that instead infects bacteria. The discovery establishes picobirnaviruses as the third known clade of RNA bacteriophages.

Oct 29, 2026·2 sources
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Top claims

  • ▪Researchers led by Tianyu Gan and David Wang established an in vivo model by gavaging germ-free mice with human stool samples to propagate picobirnaviruses.
  • ▪First discovered in 1988 from human stool samples, picobirnaviruses were assumed for decades to directly infect human cells and cause gastrointestinal diseases.
  • ▪Researchers propagated PBV-18941 in vitro for 20 passages in an anaerobic microbial community culture derived from mouse stool pellets.

Subtopics

Biomedical research1Gut microbiome1Infectious disease1Science1

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