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Mesothelioma stories

Sep 17, 2026

Experimental drug targets mesothelioma by disabling cancer's antioxidant defenses

Scientists are testing a new approach to fight mesothelioma by developing an experimental drug that kills cancer cells by disabling PRX3, an antioxidant defense mechanism that tumors use to survive oxidative stress. The counterintuitive treatment targets the aggressive asbestos-linked cancer, which currently has few effective treatment options.

Sep 17, 2026·1 source
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Top claims

  • ▪RSO-021 is administered directly into the chest via a catheter, concentrating the drug near the tumor while minimizing its circulation throughout the rest of the body.
  • ▪The experimental drug RSO-021 uses thiostrepton, a naturally occurring antibiotic, to disable the antioxidant enzyme peroxiredoxin 3 inside the mitochondria of cancer cells.
  • ▪The research on peritoneal malignancies is conducted in collaboration with Conor O'Neill, a surgical oncologist at the University of Vermont Cancer Center and University of Vermont Health.

Subtopics

Drug Approval and Clinical Trials1Drug development1Lifestyle, Wellness and Nutrition1Oxidative stress1

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