Study Reveals Aging Human Brains Replace Resident Immune Cells with Blood-Derived Cells Starting at Age 50
Researchers have overturned longstanding scientific dogma by discovering that beginning around age 50, the brain's memory center loses its longtime resident immune cells (microglia) and replaces them with more inflammatory immune cells derived from peripheral blood stem cells. This previously unrecognized migration may help explain how normal aging sets the stage for Alzheimer's disease and dementia.