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May 30, 2026

Multi-fraction stereotactic radiation improves local control for large brain metastases in phase 3 trial

The first randomized phase 3 trial comparing radiation schedules found that delivering stereotactic radiation over three to five sessions after surgery significantly improved local control and reduced cancer recurrence at the surgical site for patients with large, resected brain metastases compared with single-fraction treatment.

May 30, 2026·3 sources
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Top claims

  • ▪The multi-fraction arm in the Alliance A071801 trial showed a 94% rate of freedom from whole-brain radiation at one year, compared to 84% in the single-fraction arm.
  • ▪In the Alliance A071801 trial, treated, unresected brain metastases progressed in 4% of patients in the fractionated group compared to 11% in the single-session group.
  • ▪Historically, more than half of patients undergoing surgery for brain metastases without postoperative radiation experienced a recurrence at the surgical site within one year.

Subtopics

Cancer treatment1Clinical trials1Oncology1

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