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Sep 17, 2026

Clinical trial finds intrauterine mepivacaine reduces pain during IUD insertion

A placebo-controlled trial demonstrated that intrauterine instillation of the anesthetic mepivacaine effectively reduces pain during intrauterine device (IUD) placement, particularly in nulliparous patients. The findings address growing patient reports of pain during IUD insertion procedures.

Sep 17, 2026·3 sources
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Jul 29, 2026

Latigo reports positive mid-stage trial results for pain drug competing with Vertex's Journavx

Latigo has announced successful mid-stage clinical trial results for its non-opioid pain medication, positioning it as a potential competitor to Vertex Pharmaceuticals' pain drug Journavx in a field historically marked by development failures.

Jul 29, 2026·1 source
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Jul 24, 2026

FDA Approves First Over-the-Counter Combination Pill of Tylenol and Naproxen for Pain Relief

The U.S. Food and Drug Administration approved a nonprescription fixed-dose combination pill containing acetaminophen (650 mg) and naproxen sodium (220 mg), marketed as Tylenol with Naproxen by Kenvue. The medication provides up to 12 hours of pain relief for patients aged 12 and older.

Jul 24, 2026·9 sources
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Top claims

  • ▪In the Swedish clinical trial, 98.3% of patients in the mepivacaine group reported their pain during IUD insertion was tolerable compared to 91.4% in the placebo group.
  • ▪Patients in the Swedish clinical trial received either 10 mL of 2% mepivacaine or a sodium chloride placebo administered via a hydrosonography catheter two minutes before IUD placement.
  • ▪Dr. Nikki Zite noted that intrauterine mepivacaine instillation would have no impact on pain caused by speculum or tenaculum placement during the IUD insertion procedure.

Subtopics

Drug Approval and Clinical Trials3Clinical trials2FDA drug approval1Pharma1Women’s health1

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