Hippocampus stories

Sep 16, 2026

Scientists transplant human brain tissue into mice lacking cortex for first time

Stanford researchers genetically engineered mice without cortex or hippocampus and successfully replaced those regions with human brain organoids, creating a new platform for studying neuropsychiatric diseases including frontotemporal dementia and autism.

Sep 16, 20266 sources

Top claims

▪The human tissue transplanted into Stanford University's xenocortical mice spontaneously generated specialized cell types, including pyramidal projection neurons and von Economo neurons, which are typically absent in ordinary rodent brains
▪The human cortical cells transplanted into Stanford University's xenocortical mice failed to organize into the beautifully structured, multi-layered physical layout characteristic of a normal human cerebral cortex
▪The bioengineered mice, which Stanford University researchers led by Sergiu Pașca termed "xenocortical" mice, retained a mouse nervous system but contained a large volume of human cortical tissue

Subtopics

Autism1 Drug Approval and Clinical Trials1 Genetic engineering1

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