Critical illness stories

Oct 26, 2026

Heart drug combination reduces kidney damage in septic shock surgery, major trial finds

A major trial published in JAMA shows that a simple adjustment to drugs given during operations for septic shock could prevent thousands of patients from suffering kidney damage. Scientists from the University of Southampton and Zhejiang University School of Medicine conducted the research.

Oct 26, 20262 sources

Top claims

▪Primary corresponding author Dr. Xiangming Fang stated that the JAMA trial findings provide clear clinical evidence to update international recommendations regarding dobutamine use during emergency surgery.
▪The International Guidelines for Management of Sepsis and Septic Shock previously cited insufficient data to make a recommendation for the intraoperative use of dobutamine.
▪In the 584-patient trial, half of the surgical patients received an infusion of dobutamine alongside norepinephrine, while the control group received norepinephrine alone.

Subtopics

Cardiovascular diseases1 Clinical guidelines1 Clinical trials1 Medical research1 Perioperative medicine1 Randomized controlled trial1 Surgery1

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