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Spatial transcriptomics stories

Aug 10, 2026

Spatial transcriptomics reveals molecular programs linked to heart-transplant rejection

Researchers at Vanderbilt Health have published findings in Nature Cardiovascular Research showing that spatial transcriptomics of cardiac biopsies reveals significant cellular and molecular variation in transplant rejection that is not captured by conventional biopsy grading, potentially enabling precision medicine approaches to organ rejection treatment.

Aug 10, 2026·4 sources
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Aug 5, 2026

Researchers use spatial mapping technique to identify active genes in skeletal growth plates

Scientists at the Department of Women's and Children's Health have employed a novel spatial mapping technique to determine which genes are active in different regions of the skeleton's growth plates, providing new insights into bone growth mechanisms.

Aug 5, 2026·1 source
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Top claims

  • ▪The spatial transcriptomics study linked cell-specific gene expression patterns during acute rejection to the development of cardiac allograft vasculopathy, a chronic rejection form limiting long-term survival.
  • ▪The molecular heterogeneity within identical histologic grades may explain why clinical presentations of heart transplant rejection range from a complete lack of symptoms to cardiogenic shock.
  • ▪Solid organ transplant rejection occurs in up to 40% of organ recipients within one year of transplantation, potentially causing long-term organ failure and death.

Subtopics

Drug Approval and Clinical Trials1Precision medicine1

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