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Sep 8, 2026

BrainChild Bio raises $116M series A for pediatric brain cancer CAR-T therapy

BrainChild Bio, spun out of Seattle Children's Hospital, secured $116 million in series A funding to advance its lead CAR-T therapy BCB-276 into pivotal trials for diffuse intrinsic pontine glioma, a rare and fatal brain tumor affecting approximately 300 U.S. children annually.

Sep 8, 2026·3 sources
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Jul 4, 2026

Phase Ib Trial Shows Safety of Personalized Dendritic Cell Vaccine for Newly Diagnosed Glioblastoma

Researchers report safety and preliminary efficacy results from a phase Ib clinical trial testing personalized neoantigen-pulsed autologous dendritic cell vaccination in patients with newly diagnosed glioblastoma, a deadly brain cancer with limited treatment options.

Jul 4, 2026·2 sources
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Top claims

  • ▪BrainChild Bio is developing autologous CAR-T cell therapies designed specifically to treat rare and deadly brain cancers in pediatric patients
  • ▪BrainChild Bio's direct-to-brain CAR-T administration poses unacceptable safety risks
  • ▪BrainChild Bio administers BCB-276 directly into the cerebrospinal fluid to allow the CAR-T cells to directly access the tumor bed in the brain

Subtopics

Clinical trials2Cancer immunotherapy1CAR T-cell therapy1Drug Approval and Clinical Trials1Glioblastoma1Personalized medicine1Pharma1Rare diseases1Vaccines and Immunization Policy1

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