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Oct 21, 2026

UW Institute for Protein Design releases RFD4-Proteina AI model developed with Nvidia

The UW Medicine Institute for Protein Design, led by Nobel laureate David Baker, released RFD4-Proteina, an open-source AI model for creating proteins with specific functions, developed in collaboration with Nvidia. The release follows a computing grant from Nvidia CEO Jensen Huang's foundation that Baker described as transformational.

Oct 21, 20263 sources

Top claims

▪RFD4-Proteina was co-developed by UW doctoral students Nathaniel Corley, Maxwell Kazman, and Rafi Brent, alongside visiting University of Oxford student Kieran Didi.
▪According to a research draft, RFD4-Proteina achieved higher computational design success rates and generation throughput than evaluated baselines across four benchmark suites: protein binding, small-molecule binding, enzyme scaffolding, and DNA binding.
▪The RFD4-Proteina model co-developed by Nvidia and the University of Washington generates both protein sequences and three-dimensional structures.

People involved

Jensen Huang

Subtopics

AI applications1 AI drug discovery1 AI Models1 Compute access and pricing1 Generative AI1 Open-source AI1 Protein Structure Prediction1

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