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Sep 17, 2026

Rare inherited EGFR mutation linked to 25-fold increased lung cancer risk in nonsmokers

Researchers at Dana-Farber Cancer Institute and 23andMe Research Institute have identified a rare inherited mutation in the Epidermal Growth Factor Receptor (EGFR) gene that increases lung cancer risk by 25-fold, helping explain why 10-20% of U.S. lung cancer cases occur in people who never smoked.

Sep 17, 2026·4 sources
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Top claims

  • ▪The proportion of lung cancer cases diagnosed in people who have never smoked has been rising, though the underlying genetic factors remain poorly understood.
  • ▪The INHERIT Study, led by Dr. Jaclyn LoPiccolo and Dr. Pasi A. Jänne, is actively recruiting participants to further investigate inherited genetic risks for lung cancer.
  • ▪Investigators at the Dana-Farber Cancer Institute and the 23andMe Research Institute analyzed de-identified, aggregated genetic data from 3.3 million research-consented participants.

Subtopics

Drug Approval and Clinical Trials1Precision medicine1

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