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Zealand Pharma reports positive phase 2 obesity trial results By Investing.com

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Zealand Pharma's petrelintide shows 9.2% weight loss in Phase 2 obesity trial

Zealand Pharma announced positive Phase 2 ZUPREME-2 trial results for its amylin analog petrelintide, which achieved up to 9.2% mean body weight reduction at week 28 versus 2.0% with placebo in people with overweight or obesity and type 2 diabetes. The drug also demonstrated HbA1c reduction of up to 0.65% versus an increase of 0.23% with placebo.

Oct 7, 2026·3 sourcesWeight managementClinical trialsObesity treatmentMetabolic health
Zealand Pharma's petrelintide shows 9.2% weight loss in Phase 2 obesity trial
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Zealand, Roche topline a Phase 2 study for amylin drug, though Lilly remains an obstacle

Biospace

Zealand Pharma announces positive Phase 2 ZUPREME-2 topline results for amylin analog petrelintide in people with overweight or obesity and type 2 diabetes