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New mechanism helps cancer cells selectively produce proteins that drive tumor growth

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METTL13 enzyme found to fuel cancer growth by boosting KRAS protein production

Researchers at MD Anderson Cancer Center discovered that the METTL13 enzyme modifies translation machinery to selectively enhance production of cancer-driving proteins like KRAS, offering a potential new therapeutic target upstream of existing KRAS-targeted drugs that face resistance issues.

Oct 29, 2026·3 sourcesCancer researchOncologyCancer treatment breakthroughsBiomedical researchTargeted cancer therapyCancer & OncologyMolecular biologyDrug development
METTL13 enzyme found to fuel cancer growth by boosting KRAS protein production
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Other sources for this story

Techtimes

KRAS Drug Resistance Has Upstream Cause: METTL13 Enzyme Fuels Tumor Protein Overload

Nature

Rewired decoding fuels KRAS-driven cancer growth and drug resistance - Nature Cell Biology