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Oct 19, 2026

Mirikizumab achieves clinical remission in pediatric ulcerative colitis phase 3 trial

Eli Lilly's mirikizumab (Omvoh) achieved clinical and endoscopic remission rates in children with ulcerative colitis that exceeded historical adult placebo outcomes at week 12 in the SHINE-2 phase 3 study. The positive pediatric data could provide a competitive advantage for the IL-23p19 inhibitor in the inflammatory bowel disease market.

Oct 19, 2026·3 sources
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Top claims

  • ▪If approved by regulatory authorities for pediatric ulcerative colitis, Omvoh would become the first IL-23p19 inhibitor available for children with the condition.
  • ▪In the SHINE-2 trial, mirikizumab intravenous induction doses ranged from 5 mg/kg for patients under 40 kg to 300 mg for those over 40 kg, with maintenance doses between 50 mg and 200 mg based on weight.
  • ▪In Eli Lilly's Phase 3 SHINE-2 trial, 81% of pediatric ulcerative colitis patients achieved a clinical response after 12 weeks of induction treatment with Omvoh.

Topics

Eli LillyClinical trialsAutoimmune disease treatmentBiologic therapiesChild healthDrug developmentPharmaceutical IndustryDigestive diseases