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Oct 26, 2026

Heart drug combination reduces kidney damage in septic shock surgery, major trial finds

A major trial published in JAMA shows that a simple adjustment to drugs given during operations for septic shock could prevent thousands of patients from suffering kidney damage. Scientists from the University of Southampton and Zhejiang University School of Medicine conducted the research.

Oct 26, 2026·2 sources
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Top claims

  • ▪Primary corresponding author Dr. Xiangming Fang stated that the JAMA trial findings provide clear clinical evidence to update international recommendations regarding dobutamine use during emergency surgery.
  • ▪The International Guidelines for Management of Sepsis and Septic Shock previously cited insufficient data to make a recommendation for the intraoperative use of dobutamine.
  • ▪In the 584-patient trial, half of the surgical patients received an infusion of dobutamine alongside norepinephrine, while the control group received norepinephrine alone.

Topics

Perioperative medicineClinical guidelinesCritical illnessClinical trialsMedical researchSurgeryRandomized controlled trialCardiovascular diseases

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