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Harvard Medical School stories

Sep 7, 2026

AI-designed drug shows promise in reversing biological aging markers in clinical trial

Insilico Medicine announced that rentosertib, an experimental lung disease drug developed using artificial intelligence, demonstrated the ability to reduce biological age markers in a 42-patient trial. Six independently built aging clocks all showed patients on the drug appeared biologically younger, according to a study conducted with researchers from Harvard Medical School, Stanford University, and The Broad Institute.

Sep 7, 2026·4 sources
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Top claims

  • ▪Insilico Medicine deployed its generative chemistry platform, Chemistry42, to design the small-molecule candidate rentosertib targeting TNIK in approximately 18 months.
  • ▪The study compared patient proteomic profiles with 55,319 UK Biobank profiles to validate that rentosertib reversed typical age-related protein-expression trajectories.
  • ▪Proteomic aging clocks are reliable measures of systemic biological aging

Topics

Biomarkers & bloodwork testingLongevity & agingAI for developersAI research & benchmarksDrug discoveryLongevity biotech founders