AI-Powered Automated Oxygen Delivery System Outperforms Manual Adjustments in Clinical Trial

A clinical trial of the O2matic PRO100 automated oxygen system shows it keeps hospitalized patients in their target oxygen range 85% of the time, compared to 63% for manual care. Led by the University of Colorado Anschutz, the 300-patient trial demonstrates reduced hypoxemia and hyperoxemia with no serious adverse events. The technology is also being adapted for military and emergency transport settings.

SAVE-O2 multicenter trial design

• ▪Trial participants were hospitalized with acute respiratory illness, traumatic injury, burns, or surgical recovery, and received 1 to 10 liters of supplemental oxygen per minute.
• ▪The SAVE-O2 AI trial enrolled 300 adults receiving supplemental oxygen across four United States hospitals between May 6, 2024, and November 17, 2025.
• ▪The trial evaluated a diverse cohort where 22% of participants were classified as light skin tone, 56% as medium, and 22% as dark.
• ▪The trial randomized 152 patients to the automated oxygen titration system and 148 patients to standard clinician-managed oxygen therapy.

Automated oxygen titration technology

• ▪The O2matic PRO100 is an automated controller that continuously reads a fingertip pulse oximeter and adjusts oxygen flow between 0 and 15 liters per minute.
• ▪Standard hospital practice typically relies on nurses or respiratory therapists manually adjusting oxygen flow during periodic checks every one to eight hours.
• ▪The O2matic PRO100 is manufactured by a Danish company, carries a European CE mark, and is awaiting United States market clearance.

Clinical outcomes safety data

• ▪The automated oxygen system reduced time spent in hypoxemia to 2.0% compared to 3.6% in the standard care group.
• ▪No serious adverse events occurred in either the automated or standard care groups during the trial.
• ▪Patients in the automated group spent 85% of their time in the target oxygen range compared to 63% in the standard care group.

Military medicine applications

• ▪The Department of Defense is supporting efforts to improve automated oxygen delivery in high-stress military environments where clinician attention and oxygen resources are limited.
• ▪The AURORA project received 4.7 million dollars in Defense Department funding to ruggedize the O2matic PRO100 for military and transport environments.

Emergency transport settings

• ▪The O2matic PRO100 is being ruggedized for vibration and altitude to function during ground ambulance and helicopter transport services.
• ▪Researchers plan to evaluate the automated oxygen titration system on patients undergoing emergency transport.

Future prehospital research plans

• ▪The research team plans to conduct future clinical evaluations of the automated oxygen titration technology in prehospital settings.
• ▪Future investigations by the research team will evaluate changes in clinician workload resulting from the automated oxygen system.

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