Psychedelic harm reduction stories

Aug 5, 2026

Scientists Advance Understanding of Psychedelic Mechanisms Through New Research Tools and Theories

Researchers have developed engineered mouse models for studying psychedelic drug actions, proposed a new neurobiological theory called 'apical hypercontextualisation' to explain altered perception, and identified psychedelic candidates that may reduce side effects while maintaining therapeutic benefits.

Aug 5, 20263 sources

Apr 19, 2026

Trump Signs Executive Order to Accelerate Psychedelic Drug Reviews Including Controversial Ibogaine

President Trump signed an executive order directing the FDA to expedite reviews of psychedelic drugs including ibogaine, which has been embraced by combat veterans but remains controversial. The order was signed alongside podcast host Joe Rogan.

Apr 19, 20263 sources

Top claims

▪Unlike its parent compound quipazine, VCU-1012 did not slow digestion when tested in mice, indicating a reduction in off-target gastrointestinal side effects.
▪VCU-1012 administration reduced anxiety in mice with chemotherapy-induced mood disturbances.
▪Under the apical hypercontextualisation model, basal dendrites process local, feature-specific inputs, while apical dendrites gather remote, contextual signals and expectations from distant cortical regions and the thalamus.

People involved

Joe Rogan Donald Trump

Subtopics

Psychedelic clinical research & trials2 Ibogaine1 Neuroplasticity1 Psychedelic policy & regulation1 Psychedelic renaissance1 Psychedelics for PTSD1

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