Scientists at the University of Rochester Medicine discovered that strengthening the body's natural daily rhythms improved stroke recovery in mice by enhancing the brain's waste-clearing system and reducing inflammation. The treatment showed effectiveness even when started three days after stroke, published in the Journal of Clinical Investigation.
Scientists have identified a persistent molecular warning sign in intestinal cells that remains even when inflammatory bowel disease patients are in remission. The discovery, based on analysis of approximately 900 human gut biopsies and patient-derived mini-intestines, suggests cells can retain abnormalities that may trigger disease relapse.
Researchers have found that a combination of omega-3 fatty acids and low-dose acetylsalicylic acid (aspirin) produces results comparable to antibiotics in treating severe periodontitis, offering a potential alternative treatment approach for the gum disease.
New research has discovered that periodontitis reprograms bone marrow neutrophils through a Chac2-driven glutathione metabolic pathway, causing them to enter a highly inflammatory N1 state that drives systemic inflammation throughout the body.
A six-week clinical trial found that a daily prebiotic fiber supplement (inulin) reduced knee osteoarthritis pain comparable to supervised exercise programs, while also improving grip strength and pain sensitivity. The findings suggest a potential gut-muscle-pain connection that could offer a simpler alternative to digital physiotherapy.
Researchers found that mild inflammation during pregnancy led mouse offspring to develop persistent brain overactivity and autism-like behaviors, but remarkably, one dose of rapamycin reversed these symptoms in adult mice within hours.
BioAge Labs announced its investigational pill for cardiovascular risk prevention significantly reduced inflammation markers in an early-stage clinical study, representing potential progress in heart disease prevention.
Scientists have identified a previously unknown immune mechanism where the chloride channel PACC1 plays a crucial role in helping immune cells kill bacteria, offering a potential new therapeutic target for sepsis.
Scripps Research scientists have developed a first-in-class drug compound that reduces harmful inflammation while leaving the body's ability to fight infections intact, addressing a long-sought goal in treating autoimmune diseases.
