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Novartis heart drug failure leaves doctors seeking evidence for genetic cholesterol target | Reuters

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Novartis heart drug failure raises questions about genetic cholesterol target

The recent failure of a Novartis experimental heart drug in a large trial has raised questions among cardiologists about the widely held idea that reducing levels of genetically set cholesterol improves cardiovascular outcomes.

Nov 2, 2026·2 sourcesClinical trialsEli LillyClinical trial designClinical trial endpointsCholesterol managementHeart healthChicagoCardiovascular diseasesDrug Policy, Pricing & ApprovalBiomarkers & bloodwork testing
Novartis heart drug failure raises questions about genetic cholesterol target
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Medscape

Novartis Heart Drug Failure Leaves Doctors Seeking Evidence for Genetic Cholesterol Target