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Nature Medicine stories

Oct 29, 2026

Major international studies identify accurate non-invasive tests for metabolic liver disease

Two major international studies have delivered the strongest evidence to date on which non-invasive tests can accurately diagnose and measure the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) and its more severe form, MASH, potentially reducing reliance on liver biopsy.

Oct 29, 2026·3 sources
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Study reveals colorectal cancer in younger patients shows distinct cellular patterns

Mass General Brigham, Dana-Farber Cancer Institute, and Broad Institute researchers have identified biological differences explaining why colorectal cancer behaves more aggressively in younger people, publishing findings in Nature Medicine that could inform future prevention and treatment strategies.

Oct 29, 2026·7 sources
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Top claims

  • ▪Demand for accurate non-invasive liver diagnostics is growing as the first licensed drug treatments for MASH enter clinical practice.
  • ▪LITMUS researchers proposed a diagnostic pathway using gamma-GT for initial screening, followed by ELF or FibroScan testing, reserving advanced MRI for specialist care.
  • ▪Metabolic dysfunction-associated steatotic liver disease (MASLD) affects up to one in three adults worldwide and up to seven in 10 people with obesity or type 2 diabetes.

Topics

Biomarkers & bloodwork testingDiagnostic imagingLaboratory testingMedical imagingMetabolic healthChronic diseaseDiagnostic medicineMedical researchCancer & OncologyCancer researchEpidemiologyBiomedical researchCancerScreening programsGenomics

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