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Eli Lilly Raises 2026 Guidance as GLP-1 Drug Demand Surges in Q1
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Eli Lilly Raises 2026 Guidance as GLP-1 Drug Demand Surges in Q1

May 3, 2026

Eli Lilly reported exceptional Q1 2026 results with total revenue reaching $19.8 billion, up 56% year-over-year, driven primarily by its GLP-1 drugs Mounjaro and Zepbound which together generated $12.8 billion in combined revenue. Mounjaro sales surged 125% to $8.662 billion while Zepbound grew 80% to $4.160 billion as manufacturing capacity began catching up with global demand. The pharmaceutical giant raised its full-year 2026 revenue guidance by $2 billion and reported net income of $3.1 billion, up 41% from the prior year. Beyond GLP-1s, Eli Lilly showed strong growth in oncology with Jaypirca up 79% and neuroscience with Kisunla revenue jumping from $22 million to $124 million, while advancing its pipeline including Phase 3 studies for retatrutide in obesity and diabetes.

Q1 2026 Financial Performance and Revenue Growth

  • ▪Eli Lilly and Company total revenue across all products reached $19.8 billion in Q1 2026, up 56% from $12.7 billion in Q1 2025
  • ▪Eli Lilly and Company reported earnings per share of $3.42 in Q1 2026, a 41% increase from $2.42 in Q1 2025
  • ▪Eli Lilly and Company raised its full-year 2026 revenue guidance by $2 billion
  • ▪Eli Lilly and Company reported net income of $3.1 billion in Q1 2026, up 41% from $2.2 billion in Q1 2025
  • ▪Eli Lilly and Company reported total revenue of $12.8 billion in Q1 2026, representing a 35% increase from $9.5 billion in Q1 2025

GLP-1 Drug Portfolio Performance and Market Demand

  • ▪Eli Lilly and Company manufacturing capacity for tirzepatide-based products began to catch up with global demand in Q1 2026
  • ▪Mounjaro generated $8.662 billion in revenue in Q1 2026, a 125% increase from $3.842 billion in Q1 2025
  • ▪Mounjaro and Zepbound together generated a combined $12.8 billion in revenue in Q1 2026
  • ▪Zepbound generated $4.160 billion in revenue in Q1 2026, an 80% increase from $2.312 billion in Q1 2025

Clinical Pipeline Advances and R&D Breakthroughs

  • ▪Kisunla generated $124 million in revenue in Q1 2026 compared to $22 million in Q1 2025
  • ▪Pirtobrutinib demonstrated an 87.0% overall response rate in the intent-to-treat population compared to 78.5% for ibrutinib, with a p-value of .0035
  • ▪Pirtobrutinib demonstrated an 84.0% overall response rate in relapsed/refractory chronic lymphocytic leukemia patients compared to 74.8% for ibrutinib, with a p-value of .0175
  • ▪Jaypirca generated $165 million in revenue in Q1 2026, a 79% increase from $92 million in Q1 2025
  • ▪Eli Lilly and Company is conducting Phase 3 TRIUMPH master studies for retatrutide in obesity and type 2 diabetes
  • ▪Ebglyss generated $145 million in revenue in Q1 2026, a 141% increase from $60 million in Q1 2025

Perspective of Eli Lilly management

  • ▪Eli Lilly's diversified portfolio beyond GLP-1 drugs demonstrates strong growth across oncology and neuroscience therapeutic areas

Perspective of Investors and financial analysts

  • ▪Mounjaro and Zepbound's combined $12.8 billion revenue represents approximately 65% of Eli Lilly's total Q1 2026 revenue of $19.8 billion
  • ▪Eli Lilly's $2 billion increase in full-year 2026 revenue guidance signals management confidence in sustained GLP-1 demand throughout the year

Perspective of Healthcare providers and patients

  • ▪Improved tirzepatide manufacturing capacity in Q1 2026 suggests reduced wait times and better availability for patients seeking Mounjaro and Zepbound prescriptions
  • ▪The 125% year-over-year growth in Mounjaro revenue indicates expanding patient access to GLP-1 treatments for type 2 diabetes

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Lilly Q1 2026 Financial Results: Guidance Raised as Demand Surges
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Lifestyle, Wellness and NutritionPublic healthcareZepboundEli LillyCorporate earningsGLP-1 medicationsPharmaceutical IndustryPharma